The World's First Clinically Evidenced Strain For “Microplastic Excretion and Detoxification": 

DePlastox™ Lactiplantibacillus plantarum PD01

Extensive Studies Have Reported Microplastics Found in Human Organs¹. Microplastic accumulation in various organs is associated with a range of human health risks, including intestinal inflammation, obesity, cardiovascular disease, cancer, and dementia^2~6.

DePlastox™ PD01 is the World's First Clinically Evidenced Strain For Microplastic Excretion and Detoxification. 

DePlastox™ PD01 is a human-derived strain, isolated from a healthy young indivisual with high microplastic-excretion ability⁷, belonging to Lactiplantibacillus plantarum—a species with a long history of safe human consumption.

Instead of excessive gavage of PS microbeads, DePlastox™ PD01 exerts a superior microplastic excretion and detoxification efficacy in a murine model closely mimicking human exposure to microplastics⁷:

- largely promotes excretion of variou types of microplastics;

- inhibits oxidative stress, inflammatory and obesity symptoms induced by microplastics; 

- reduces the translocation of microplastics in gut through its selective absorption and aggregation of microplastics, enhancement of tight junction and reducing of microplatic-induced epithelial damage;

- features a powerful hydrolytic enzyme system that promotes dietary fiber hydrolysis, boosts intestinal SCFA levels, enhances gut microbiota diversity, and delivers comprehensive gut health benefits. 

Most importantly, DePlastox™ PD01 is backed by the world's first human RCT data, showing a significant reduction in residual plastic-related toxic substances in the human body after a 6-week intervention⁸. 

Reference: 

1. M H. Lamoree, et al., Nature Medicine, 31, 2873-2887, 2025.

2. Z. Yan, et al., Environmental Science & Technology, 56, 414-421, 2022.

3. Y. Hong, et al., Journal of Hazardous Materials, 476, 135125, 2024.

4. R. Marfella, et al., New England Journal of Medicine, 390, 900-910, 2024.

5. Li, R. et al. Nature Health Doi: 10.1038/s44360-026-00091-4, 2026.

6. AJ. Nihart, et al., Nature Medicine, 31, 1114-1119, 2025.

7. L. Zhao, et al., NPJ Science of Food, DOI: 10.1038/s41538-026-01045-6, 2026.

8. R. Lu, et al., medRxiv preprint (NCT07416214), 2026. DOI: 10.64898/2026.08.12.26360001, 2026