High-Altitude Anti-Aging Powers：

DePlastox™ Lactiplantibacillus plantarum PD01 (for Reducing the Risk of Microplastic-induced Accelerated Aging^1,2,3)

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Lactiplantibacillus plantarum AL4510 (Slow Hypoxia-induced Accelerated Aging & Alleviate Symptoms of Premature Ovarian Failure^4,5)

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Lacticaseibacillus paracasei TDM-2 (High Antioxidant Activity for Reversing Gut Aging and Mitochondrial Protection^6,7)

Lactiplantibacillus plantarum AL4510 was isolated fromnatural goat milk in a high-altitude pasture (4,510m) in the Ngari region of Tibet, a remote area untouched by industrial pollution.

Mechanism & Efficacy of L. plantarum AL4510

AL4510 regulates glutathione biosynthesis, enhances antioxidant capacity, and protects cells from reactive oxygen species and toxic substances. 

Anti-Aging via Microbiota-Metabolite Axes

• Dynamically modulates specific gut microbiota-metabolite axes to meet targeted physiological demands.

• Alleviates D-galactose-induced aging by activating the Christensenella-spermidine axis.

• Mitigates hypobaric hypoxia-induced aging by fortifying the Akkermansia-mediated intestinal barrier and upregulating energy metabolism pathways.

Gut-Ovary Axis Benefits

• Alleviates POF Symptoms: Effectively mitigates Premature Ovarian Failure (POF) induced by repeated superovulation in mice.

• Restores Ovarian Function: Rejuvenates ovarian reserve and restores estrogen secretion.

• Dual Anti-Inflammatory & Antioxidant Action: Elevates antioxidant and anti-inflammatory levels in both ovaries and the colon.

• Gut Barrier Protection: Safeguards the integrity and stability of the intestinal barrier.

• Microbiota Modulation: Regulates gut flora and promotes the production of Short-Chain Fatty Acids (SCFAs), effectively alleviating ovarian damage and boosting reproductive health.

Reference: 

1. Moon, H., et al. Sci Rep 14, 23920 (2024). https://doi.org/10.1038/s41598-024-74892-6

2. Nihart, A.J., et al. Nat Med 31, 1114–1119 (2025). https://doi.org/10.1038/s41591-024-03453-1

3. L. Zhao, et al., NPJ Science of Food, DOI: 10.1038/s41538-026-01045-6, 2026. & R. Lu, et al., medRxiv preprint (NCT07416214), 2026. DOI: 10.64898/2026.08.12.26360001, 2026

4. Pang, M., et al. npj Sci Food  (2026). https://doi.org/10.1038/s41538-026-01102-0

5. H. Sun, et al. Food Funct. 2026; 17 (18): 8016–8034. https://doi.org/10.1039/d6fo02156e

6. Fan, X., et al., Applied Biochemistry and Microbiology, 2026. DOI: 10.1134/S0003683826600880

7. Yang, T., et al. Foods 2023, 12, 1814. https://doi.org/10.3390/foods12091814